Simultaneous Application of High-Intensity Focused Electromagnetic and Synchronized Radiofrequency for Fat
Robert A Weiss1, Jan Bernardy2, Frantisek Tichy3
1Maryland Laser Skin, & Vein Institute, Hunt Valley, Maryland.
Background:
Radiofrequency (RF) and high-intensity focused electromagnetic (HIFEM) technologies are used for noninvasive body shaping as standalone modalities.
Objective:
To examine the effects of novel synchronized RF and HIFEM on subcutaneous adipose tissue in a porcine animal model.
Materials And Methods:
Seven large white pigs aged 6 months received 3 abdominal treatments of simultaneous application of synchronized RF and HIFEM (30 minutes, once per week). Punch biopsies of treated and control subcutaneous tissue were collected at the baseline, 4 days, 2 weeks, 1 month, and 2 months. Specimens were examined by light and scanning electron microscopy. Adipocyte volume was analyzed. Fat tissue temperature was measured in situ (fiber optic probes) and superficially (thermal imager).
Results:
Fat layer was heated to temperatures of 42 to 45°C. Signs of fat apoptosis (shape alternations and pyknotic nuclei) appeared at day 4 and peaked between 2 weeks and 1 month. Adipocyte volume decreased significantly (p < .001) by 31.1% at 2 weeks, 1 month (-23.6%), and 2 months (-22.0%). Control samples showed healthy adipocytes. Scanning electron microscopy micrographs corroborated histology findings, showing flattened, volume-depleted and disrupted adipocytes.
Conclusion:
Synchronized RF with HIFEM procedure resulted in a significant and sustained fat reduction with no adverse events.
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