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Regular Resistance Training Enhances Fibrinolytic Potential but Does Not Affect Coagulation.

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This study found that an 8-week resistance training (RT) program reduced plasminogen activator inhibitor-1 (PAI-1), decreasing fibrinolysis inhibition. These findings suggest RT may lower thrombotic event risk.

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Area of Science:

  • Exercise Physiology
  • Hemostasis Research
  • Biochemistry

Background:

  • Resistance training (RT) is known to improve body composition and strength.
  • The effects of RT on hemostasis, particularly coagulation and fibrinolysis, require further investigation.
  • Understanding these effects is crucial for assessing the overall health benefits of RT.

Purpose of the Study:

  • To determine the impact of an 8-week whole-body RT program on markers of coagulation and fibrinolysis in healthy adults.
  • To investigate changes in specific hemostatic factors following a structured RT intervention.

Main Methods:

  • Sixteen healthy participants (23 ± 5 years) underwent an 8-week RT program (3x/week, 2-3 sets, 8-12 reps, 60-80% 1RM).
  • Assessed strength, body composition, and circumferences pre- and post-training.
  • Analyzed plasma for tissue plasminogen activator (tPA) activity and antigen, plasminogen activator inhibitor-1 (PAI-1) activity and antigen, fibrinogen, and coagulation factors VII (FVII) and VIII (FVIII).

Main Results:

  • RT significantly increased lean mass and strength (chest press, leg press) (P < 0.05).
  • A significant decrease in PAI-1 activity and antigen was observed post-RT (P < 0.05).
  • No significant changes were found in tPA activity/antigen, fibrinogen, FVII, or FVIII.

Conclusions:

  • The 8-week RT program effectively decreased PAI-1 levels, indicating reduced inhibition of fibrinolysis.
  • Coagulation parameters remained unaffected by the RT intervention.
  • These results suggest that regular RT may favorably modulate thrombotic risk by improving fibrinolytic capacity.