Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic changes during post-ischaemic reperfusion.

R Ferrari1, C Ceconi, S Curello

  • 1Università degli Studi di Brescia, Cattedra di Cardiologia, Italy.

Journal of Molecular and Cellular Cardiology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sporadic Abdominal Wall Desmoid type Fibromatosis: treatment paradigm after thirty two years.

BMC surgery·2018
Same author

Abdominal wall reconstruction after desmoid type fibromatosis radical resection: Case series from a single institution and review of the literature.

International journal of surgery case reports·2017
Same author

Gender differences in the effects of cardiovascular drugs.

European heart journal. Cardiovascular pharmacotherapy·2017
Same author

High sensitive thyroglobulin assay on thyroxine therapy: can it avoid stimulation test in low and high risk differentiated thyroid carcinoma patients?

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2013
Same author

Twenty years experience in oncologic surgery for primary cardiac tumors.

Il Giornale di chirurgia·2013
Same author

Preliminary enquiry into the availability, price and quality of malaria rapid diagnostic tests in the private health sector of six malaria-endemic countries.

Tropical medicine & international health : TM & IH·2011
Same journal

Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction.

Journal of molecular and cellular cardiology·2026
Same journal

SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension.

Journal of molecular and cellular cardiology·2026
Same journal

Therapeutic impact of normal dietary patterns on diabetic cardiomyopathy: Transcriptomic and proteomic insights.

Journal of molecular and cellular cardiology·2026
Same journal

Structural, biophysical and cellular assessment of filamin C M82K: A test case for VUS interpretation in cardiomyopathy.

Journal of molecular and cellular cardiology·2026
Same journal

Precision modification of heart failure signaling by CRISPR-Cas9 base editing.

Journal of molecular and cellular cardiology·2026
Same journal

Retraction notice to 'Sam68 impedes the recovery of arterial injury by augmenting inflammatory response' [Journal of Molecular and Cellular Cardiology 137 (2019) 82-92].

Journal of molecular and cellular cardiology·2026
See all related articles

Rapid reperfusion after ischemia is crucial for heart recovery. Prolonged ischemia leads to cell damage, mitochondrial dysfunction, and impaired ATP synthesis, but high magnesium and low calcium solutions can mitigate these effects.

Area of Science:

  • Cardiology
  • Biochemistry
  • Physiology

Background:

  • Ischemia and reperfusion injury significantly impact myocardial function.
  • Metabolic changes during these events are critical for understanding heart muscle recovery.

Purpose of the Study:

  • To investigate the metabolic alterations during ischemia and reperfusion in patients with coronary artery disease and in isolated rabbit hearts.
  • To determine the time course of these changes and their impact on myocardial contractility and mitochondrial function.

Main Methods:

  • Measurement of arterial and coronary sinus differences for oxygen, lactate, glucose, free fatty acid, and creatine kinase in patients undergoing thrombolysis.
  • Studies on isolated perfused rabbit hearts to assess recovery after varying durations of ischemia and reperfusion protocols.

Related Experiment Videos

Main Results:

  • Early reperfusion restored aerobic metabolism and contractility in patients; prolonged ischemia led to irreversible mitochondrial damage.
  • Rabbit heart studies confirmed that reperfusion speed influences recovery and prolonged ischemia causes cell damage, ion permeability breakdown, and altered intracellular calcium and magnesium levels.
  • High magnesium and low calcium reperfusion solutions reduced mitochondrial calcium overload, preserving ATP synthesis and partial recovery of heart function.

Conclusions:

  • The duration of ischemia and the speed of reperfusion are critical determinants of myocardial recovery.
  • Ischemia-reperfusion injury involves significant metabolic derangements, including mitochondrial calcium overload.
  • Therapeutic strategies involving magnesium and calcium modulation may protect the ischemic heart muscle during reperfusion.