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Brainstem Dysfunction in Healthy Aging.

S G Mueller1, A M Muller1

  • 1Dept. of Radiology, University of California, San Francisco, CA.

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This summary is machine-generated.

Older adults show altered brainstem-brain connectivity during specific brain states, impacting cognitive function. This age-related weakening affects network synchronization and working memory performance.

Keywords:
agingbrainstemdysfunctionfMRIgraph analysissegmentation

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Area of Science:

  • Neuroscience
  • Aging Research
  • Brain Imaging

Background:

  • The brainstem is crucial for regulating brain activity and information processing.
  • Understanding age-related changes in brainstem function is vital for cognitive health.

Purpose of the Study:

  • To investigate age-related alterations in brainstem-brain interactions during distinct brain states.
  • To analyze dynamic changes in functional connectivity using task-free functional MRI (fMRI).

Main Methods:

  • Studied 79 young and 51 older adults using advanced brainstem segmentation and fMRI analysis.
  • Identified 15 brain states via hierarchical clustering and characterized them using graph theory.
  • Statistical analysis included Kruskal-Wallis tests and Spearman correlations.

Main Results:

  • One specific brain state (cluster 21) was more prevalent in older adults, showing reduced modular strength and brainstem-cortical connectivity.
  • Age-related gray matter differences correlated with this brain state's modular strength.
  • Increased duration of brain state 21 was linked to poorer working memory.

Conclusions:

  • Findings suggest an age-related decline in brainstem network synchronization, impacting cortical and subcortical networks.
  • This neural alteration in older adults is associated with diminished working memory capacity.