Related Experiment Video
Updated: Nov 2, 2025

High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury
Published on: June 16, 2018
Pediatric Ocular Injury Due to Hand Sanitizer Exposure: An Emerging Hazard
Lauren M Wasser1, Jordanna H Koppel2, David Zadok1
1From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem.
Insights
Alcohol-based hand rub (ABHR) exposure caused childhood ocular injuries during the COVID-19 pandemic. Prompt treatment ensured good visual outcomes, but safe storage is crucial.
Area of Science:
- Ophthalmology
- Pediatrics
- Public Health
Background:
- The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to increased use of alcohol-based hand rub (ABHR).
- Ocular exposure to ABHR can cause chemical injuries in children.
- Understanding the incidence and severity of these injuries is crucial for prevention and management.
Purpose of the Study:
- To describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children during the SARS-CoV-2 pandemic.
- To compare ocular injury rates from ABHR between the pandemic period and the preceding year.
Main Methods:
- Retrospective, single-center observational study.
- Included children 10 years or younger with ABHR-induced ocular injury.
- Compared data from February 21, 2020, to October 11, 2020, with the same period in 2019.
Main Results:
- Nine pediatric patients presented with ABHR-induced ocular injuries during the study period.
- Three patients required hospitalization for severe epithelial defects, with complete resolution in 12-19 days.
- No long-term irreversible damage or vision loss was observed with prompt treatment.
Conclusions:
- Increased alcohol-based hand rub (ABHR) use during the SARS-CoV-2 pandemic resulted in childhood ocular injuries.
- Prompt irrigation, topical medications, and lubrication led to favorable visual outcomes.
- Alcohol-based hand rub (ABHR) should be considered potentially toxic and stored safely away from children.
Objectives:
The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.
Methods:
A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. The same period from 2019 was studied and a comparison was performed between the 2 years. Outcome measures included the number of subjects with ocular injury due to ABHR, extent of ocular epithelial defects, length of hospitalization and time to resolution.
Results:
A total of 9 patients presented to the Pediatric Emergency Department after sustaining ocular chemical injuries from ABHR during this period. Treatment included immediate irrigation followed by topical antibiotics, steroids, and lubrication. Six children were discharged and followed as outpatients with no reported adverse ocular sequelae. Three patients exhibited epithelial defects involving 85% to 100% of the cornea, 30% to 75% of the conjunctiva and required inpatient treatment ranging from 4 to 11 days. All patients experienced a complete resolution of the ocular epithelial defects after 12 to 19 days. No long-term irreversible damage was observed and visual acuity returned to normal in all patients.
Conclusions:
The utilization of ABHR during the severe acute respiratory syndrome coronavirus 2 pandemic resulted in childhood ocular injury. Prompt treatment led to good visual outcomes. These products should be regarded as potentially toxic and stored out of the reach of young children.
More Related Videos
07:27Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
10:13Eye Irritation Test EIT for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial RhCE Tissue Model
Published on: August 23, 2015
Related Concept Videos
Hand hygiene
Hand washing...
PPE Use in Healthcare Settings II: Doffing
Handwashing I: Introduction and Types of Equipment
Hand wash basins in clinical areas should have faucets that can be turned on and off without using the hands; that is, they should be non-touch or lever-operated....
Handwashing II: Pre-procedure and Initial Procedure Steps
The hand washing procedure itself includes the following steps. First, cover cuts, if any, on hands with a waterproof dressing. Cuts and abrasions can become contaminated with bacteria hindering the ability to clean the area thoroughly. In addition, repeated hand washing can worsen an injury. The nails must be short and clean, without nail...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Personal Protective Equipment