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Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

Peng Xie1, Yushu Wang2, Dengshuai Wei3

  • 1Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. xinzhan.mao@csu.edu.cn and Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. hhxiao@iccas.ac.cn.

Journal of Materials Chemistry. B
|June 11, 2021
PubMed

Insights

Nanoparticle drug delivery systems offer a promising strategy to overcome platinum drug resistance in cancer therapy. This review explores nanoparticle advantages and design strategies to enhance chemotherapy efficacy.

Area of Science:

  • Oncology
  • Nanomedicine
  • Drug Delivery

Background:

  • Platinum drugs are vital cancer therapeutics but face significant challenges due to cancer cell drug resistance.
  • Drug resistance severely limits the clinical efficacy of platinum-based chemotherapy.
  • Developing strategies to overcome chemoresistance is critical for improving patient outcomes.

Purpose of the Study:

  • To review common mechanisms of platinum drug resistance in cancer.
  • To highlight the advantages of nanoparticle-based drug delivery systems for platinum drugs.
  • To discuss recent advancements and design considerations for nanoparticle delivery platforms to overcome chemoresistance.

Main Methods:

  • Literature review and synthesis of existing research on platinum drug resistance.
  • Analysis of nanoparticle properties and their role in drug delivery and overcoming chemoresistance.
  • Discussion of strategies for designing effective nanoparticle-based platinum drug delivery systems.

Main Results:

  • Nanoparticles offer multifunctionality, including targeted drug delivery, tumor microenvironment modulation, and integration of therapeutic agents.
  • Various nanoparticle strategies are being developed to combat platinum drug resistance.
  • Effective design of delivery platforms is key to enhancing chemotherapy efficacy.

Conclusions:

  • Nanoparticle-based delivery systems represent a significant advancement in overcoming platinum drug resistance.
  • Further research into rational design of these systems can improve platinum-based chemotherapy outcomes.
  • These strategies hold promise for more effective cancer treatment.

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