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Acyclovir prevents reactivation of herpes simplex labialis in skiers
S L Spruance1, M L Hamill, W S Hoge
1Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.
JAMA
|September 16, 1988
Abstract:
To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.