Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin and glucocorticoid hormones.

M Familari1, J W Funder

  • 1Medical Research Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia.

The Japanese Journal of Experimental Medicine
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary Aldosteronism: New Answers, New Questions.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2015
Same author

P11. Differentially expressed micro-RNAs in microparticles from haemoglobin perfused placentas.

Pregnancy hypertension·2015
Same author

Progress in primary aldosteronism 2.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2012
Same author

Primary aldosteronism: are we missing the wood for the trees?

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2012
Same author

Progress in primary aldosteronism.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2010
Same author

Distribution, Isolation and Sequence Analysis of the C-Terminal Heptapeptide of Pro-Enkephalin A (YGGFMRF) from the Ovine Median Eminence.

Journal of neuroendocrinology·2009

Melatonin does not counteract the effects of dexamethasone, a synthetic glucocorticoid, on body weight, thymus, or adrenal glands in female rats. Binding studies confirm melatonin is not a glucocorticoid antagonist.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Synthetic glucocorticoids like dexamethasone are potent regulators of physiological processes.
  • Melatonin is a hormone with diverse biological functions, including potential interactions with the endocrine system.

Purpose of the Study:

  • To investigate whether melatonin antagonizes the effects of dexamethasone on key physiological parameters in female rats.
  • To determine if melatonin competes with dexamethasone for binding to glucocorticoid receptors.

Main Methods:

  • Female rats were administered dexamethasone (2.5, 5, or 10 µg/day) in drinking water for 7 days.
  • Concomitant administration of melatonin (0.2 or 1.0 mg, i.p.) at different times of day.
  • Body weight gain, thymus weight, and adrenal weight were measured.
  • Competition binding assays were performed using 3H-dexamethasone and thymus cytosol.

Related Experiment Videos

Main Results:

  • Dexamethasone significantly reduced body weight gain, thymus weight, and adrenal weight.
  • Melatonin administration did not alter these dexamethasone-induced effects.
  • Melatonin did not compete with 3H-dexamethasone for binding to glucocorticoid receptors.

Conclusions:

  • Melatonin does not appear to act as a glucocorticoid antagonist based on these physiological and binding data.
  • The findings suggest a lack of direct interaction between melatonin and the glucocorticoid receptor pathway investigated.