Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A proposal for simplifying the labelling of sunscreens.

International journal of cosmetic science·2026

Same author

A manifesto for informed sun protection advice in relation to sunscreens.

International journal of cosmetic science·2026

Same author

Mutation burden of narrowband ultraviolet B phototherapy (NB-UVB) in human skin: relevance to NB-UVB lifetime exposures and skin cancer surveillance.

The British journal of dermatology·2025

Same author

No Significant Skin Cancer Risk From UV/LED Nail Lamp Radiation Exposure.

International journal of dermatology·2025

Same author

When should sunscreen be applied: The balance between health benefit and adverse consequences to humans and the environment.

International journal of cosmetic science·2023

Same author

Is sunscreen alone effective at preventing sunburn on a high-solar beach vacation: A modeling study?

Photochemistry and photobiology·2023

Search research articles

Related Experiment Video

Updated: Nov 2, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Erythema and Acclimatization Following Repeated Sun Exposure: A Modeling Study.

¹Dermatological Sciences, Newcastle University, Newcastle Upon Tyne, UK.

Photochemistry and Photobiology

|June 12, 2021

Summary

This summary is machine-generated.

A new computational model predicts skin erythema and acclimatization to solar ultraviolet (UV) radiation. This model aids in understanding sun exposure effects throughout the year for various skin types and latitudes.

More Related Videos

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

Related Experiment Videos

Last Updated: Nov 2, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

Area of Science:

Photobiology
Computational modeling
Dermatology

Background:

Solar ultraviolet (UV) radiation exposure causes erythema (sunburn) and skin adaptation.
Understanding the dynamic interplay between UV exposure, erythema, and acclimatization is crucial for skin health.
Previous models may not fully capture the time-varying nature of these responses over a yearly cycle.

Purpose of the Study:

To develop and validate a computational model for predicting time-varying erythema and skin acclimatization to repeated solar UV exposure.
To investigate the influence of seasonal variations, latitude, and skin type on UV-induced erythema and photoadaptation.
To provide a tool for planning future experimental studies and understanding mechanistic responses to UV radiation.

Main Methods:

Development of a computational model based on three key physiological responses: erythemal response to UV dose, and time courses of erythema and adaptation after single UV exposure.
Validation of the model by comparing its predictions with experimental data.
Simulation of daily sun exposure scenarios over a year at different latitudes and for various sun-reactive skin types.

Main Results:

The computational model demonstrated good agreement between its predictions and experimental observations.
The model illustrates that intermittent sun exposure can lead to erythema, particularly in late spring and early summer.
Results highlight significant variations in skin photoadaptive responses throughout the year, influenced by latitude and individual skin type.

Conclusions:

The developed computational model accurately predicts erythema and acclimatization following repeated solar UV exposure.
The model provides valuable insights into the seasonal and individual variability of skin's response to UV radiation.
This mathematical approach complements observational data and can guide future research in photobiology and dermatology.