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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Cytoskeletal Linker Proteins - Plakins01:09

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Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Reply to Martorell Calatayud et al., "Cost-Consequence Analysis of Secukinumab vs Adalimumab in Moderate-to-Severe Hidradenitis Suppurativa".

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Related Experiment Video

Updated: Nov 2, 2025

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
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Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

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Autoinflammatory keratinitzation diseases (AIKDs.

A Peña-Rosado1, N Riera-Martí2, V Expósito-Serrano2

  • 1Servicio de Medicina, Consorci Corporació Sanitària Parc Taulí, Universidad Autónoma de Barcelona, Spain.

Actas Dermo-Sifiliograficas
|June 12, 2021
PubMed
Summary

Autoinflammatory keratinization diseases (AiKDs) involve genetic factors, inflammation, and autoimmunity, causing skin keratinization issues. Understanding this link is crucial for new treatments targeting both inflammation and keratinization.

Keywords:
AutoinflamatorioAutoinflammatoryHidradenitisKeratinizationKeratosis lichenoidesPitiriasis rubra pilarisPityriasis rubraPsoriasisQueratinizaciónQueratosis liquenoide

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Area of Science:

  • Dermatology and Genetics
  • Investigates the intersection of inflammatory and autoimmune pathways in skin disorders.

Background:

  • Autoinflammatory keratinization disease (AiKD) is a new concept for skin conditions with genetic roots.
  • These diseases feature combined autoinflammatory and autoimmune mechanisms affecting skin keratinization.

Purpose of the Study:

  • To introduce and define Autoinflammatory Keratinization Disease (AiKD).
  • To highlight the genetic underpinnings and pathogenic mechanisms of AiKDs.
  • To emphasize the need for integrated therapeutic strategies.

Main Methods:

  • Review of recent advances in medical genetics.
  • Identification of genetic mutations (IL36RN, CARD14, NLRP1) linked to specific AiKDs.
  • Conceptual framework for understanding AiKD pathophysiology.

Main Results:

  • Specific genetic mutations are associated with conditions like pustular psoriasis, acrodermatitis continua, hidradenitis suppurativa, pityriasis rubra pilaris, and keratosis lichenoides chronica.
  • AiKD pathophysiology may extend to non-monogenic disorders.
  • The interplay between inflammation and keratinization is key.

Conclusions:

  • Understanding the bidirectional relationship between inflammation and keratinization is vital for effective patient management.
  • Future drug development should target both inflammatory and keratinization pathways.
  • New AiKDs are anticipated to be identified.