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Related Experiment Video

Updated: Nov 2, 2025

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The squirrel monkey model in clinical neuroscience.

Julie Royo1, Stephanie J Forkel2, Pierre Pouget1

  • 1Brain Connectivity and Behaviour Laboratory, Sorbonne University, Paris, France; Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, ICM, Movement Investigation and Therapeutics Team, Paris, France.

Neuroscience and Biobehavioral Reviews
|June 12, 2021
PubMed
Summary
This summary is machine-generated.

Squirrel monkeys offer a promising translational model for brain research, complementing rodent and macaque studies. Advancements in technology and open science make them ideal for discovering new treatments for brain pathologies.

Keywords:
Animal modelClinical neuroscienceNeuroimagingPrimatesTranslational

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Area of Science:

  • Neuroscience
  • Translational Research
  • Comparative Neurology

Background:

  • Animal models are crucial for understanding human brain function and pathology.
  • Rodent models are widely used but have limitations in mimicking certain human brain disorders.
  • Macaque models offer greater CNS similarity but are costly and have small sample sizes.

Purpose of the Study:

  • To evaluate the potential of squirrel monkeys as a translational model in neuroscience.
  • To identify how squirrel monkeys can bridge research gaps between rodents, macaques, and humans.
  • To highlight the impact of new technologies on utilizing squirrel monkey models.

Main Methods:

  • Review of existing literature on animal models in neuroscience.
  • Comparative analysis of anatomical, physiological, and behavioral similarities across species.
  • Discussion of emerging technologies like ultrasound imaging and miniaturization.

Main Results:

  • Squirrel monkeys present a unique combination of similarities to humans and practical advantages.
  • They can complement existing models, offering a valuable middle ground.
  • Technological advancements enhance the feasibility and scope of research using squirrel monkeys.

Conclusions:

  • The squirrel monkey model holds significant potential for advancing translational neuroscience.
  • It offers a viable solution to limitations faced with current rodent and macaque models.
  • This model is poised to drive new discoveries in diagnosing and treating brain pathologies.