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Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Udupi, Karnataka, India.
Abstract:
Regardless of progress in therapy management which are developed for colon cancer (CC), it remains the third most common cause of mortality due to cancers around the world. Conventional medicines pose side effects due to untoward action on non-target cells. Their inability to deliver drugs to the affected regions of the colon locally, in a reproducible manner raises a concern towards the efficacy of therapy. In this regard, nanoparticles emerged as a promising drug delivery system due to their flexibility in designing, drug release modulation and cancer cell targeting. Not only are nanoparticles making their way into colon cancer research in the revolution of conventional onco-therapeutics, but they also offer promising scope in the development of colon cancer vaccines and theranostic tools. However, there are challenges with respect to drug delivery using nanoparticles, which may hamper the delivery of these novel carriers to the colon. The present review addresses recent advents in nanotechnology for colon-specific drug delivery (CDDS) which may help to overcome the existing challenges and intends to recognize futuristic potentials in the treatment of CC with CDDS.
Insights
Nanoparticles offer a promising approach for colon cancer (CC) treatment by enabling targeted drug delivery and overcoming conventional therapy limitations. This review explores advancements in nanotechnology for colon-specific drug delivery (CDDS) to improve CC therapeutic outcomes.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Colon cancer (CC) remains a leading cause of cancer mortality globally.
- Conventional therapies for CC face challenges including side effects and localized, reproducible drug delivery.
- Nanoparticles present a novel solution for targeted drug delivery, vaccine development, and theranostic tools in CC research.
Purpose of the Study:
- To review recent advancements in nanotechnology for colon-specific drug delivery (CDDS).
- To highlight how nanotechnology can overcome current challenges in CC drug delivery.
- To explore the future potential of CDDS in colon cancer treatment.
Main Methods:
- Literature review of recent advancements in nanotechnology for colon-specific drug delivery.
- Analysis of nanoparticle-based strategies for colon cancer therapy.
- Discussion of challenges and future directions in CDDS.
Main Results:
- Nanoparticles offer design flexibility, controlled drug release, and cancer cell targeting capabilities.
- Nanotechnology is revolutionizing conventional cancer therapeutics and enabling new approaches like vaccines and theranostics.
- Despite challenges, nanotechnology holds significant promise for improving colon-specific drug delivery.
Conclusions:
- Nanotechnology-based colon-specific drug delivery (CDDS) systems show great potential to enhance colon cancer (CC) treatment efficacy.
- Addressing current delivery challenges is crucial for realizing the full therapeutic benefits of nanoparticles in CC.
- Future research in CDDS is vital for advancing colon cancer therapy and improving patient outcomes.
