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Juvenile idiopathic arthritis in Jordan: single center experience
Raed M Alzyoud1, Motasem O Alsuweiti2, Heba Q Almaaitah2
1Pediatric Immunology, Allergy and Rheumatology Division, Queen Rania Children's Hospital, Royal Medical Services, King Abdullah II St 226, P. O Box 11855, Amman, Jordan. raedalzyoud@gmail.com.
Insights
This study of pediatric patients in Jordan found oligoarticular juvenile idiopathic arthritis (JIA) to be the most common subtype. Further population-based research is recommended for a comprehensive understanding of JIA patterns.
Area of Science:
- Pediatric Rheumatology
- Clinical Immunology
- Child Health
Background:
- Juvenile idiopathic arthritis (JIA) is a complex autoimmune disorder affecting children under 16.
- Understanding JIA's clinical and laboratory features is crucial for effective management.
- This study focuses on JIA characteristics within a Jordanian pediatric cohort.
Purpose of the Study:
- To evaluate the clinical and laboratory features of JIA in Jordanian children.
- To identify the most prevalent JIA subtypes in the studied population.
- To establish a baseline for JIA epidemiology in Jordan.
Main Methods:
- Retrospective analysis of electronic medical records from 2015-2019.
- Inclusion of pediatric patients diagnosed with JIA according to ILAR criteria.
- Data collection included demographics, JIA subtype, laboratory results, and outcomes.
Main Results:
- A cohort of 210 pediatric patients (94 males, 116 females) was analyzed.
- Oligoarticular JIA was the most frequent subtype (54.7%), followed by systemic (17.1%) and polyarticular (12.3%).
- Antinuclear antibody (ANA) positivity was observed in 33.6% of patients, and uveitis in 14.2%.
Conclusions:
- This is the first report on JIA in Jordan, providing valuable regional data.
- Oligoarticular JIA is the predominant subtype in this Jordanian cohort.
- Future population-based studies are recommended for a more comprehensive understanding of JIA in Jordan.
Background:
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders, including all forms of arthritis, which develops in children who are less than 16 years old. This study aimed to evaluate the clinical and laboratory features of JIA in a single center in Jordan.
Methods:
A retrospective analysis of the electronic medical records of Pediatric patients diagnosed with JIA based on the International League of Associations for Rheumatology (ILAR) criteria during the period from 2015 to 2019 at the Pediatric Rheumatology Clinic in the Queen Rania Children's Hospital. All patients were below the age of 14 years at the time of diagnosis and followed for at least 6 months. Collected data consisted of age, gender, age at initial presentation and diagnosis, JIA subtype, laboratory data, treatment options, and outcome.
Results:
A total of 210 patients were included in this cohort (94 males and 116 females) with the mean age at diagnosis and mean age at onset of 5.33 ± 3.40 years and 5.08 ± 3.40 years (range: 7 months - 14 years), respectively. Oligoarticular JIA was the commonest subtype (54.7%), followed by systemic arthritis (17.1%) and polyarticular arthritis (12.3%). ANA was positive in 70 patients (33.6%). Uveitis occurred in 30 (14.2%) patients.
Conclusion:
To the best of our knowledge, this study on this cohort is the first report on JIA in Jordan, in comparison with other regionally and internationally published reports. Oligoarticular JIA was found to be the most common subtype. For detailed knowledge on JIA characteristics and patterns, a population-based, rather than a single center study, should be conducted in Jordan.
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