Related Experiment Video
Updated: Nov 2, 2025
Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
Post SARS-CoV-2 infection reactive arthritis: a brief report of two pediatric cases
Reza Sinaei1,2, Sara Pezeshki3,4, Saeedeh Parvaresh5
1Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Insights
Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection can cause reactive arthritis in children, presenting as joint swelling after initial respiratory symptoms. Early recognition and NSAID treatment are key for recovery.
Area of Science:
- Pediatric Rheumatology
- Infectious Diseases
- Immunology
Background:
- Preliminary reports indicated milder SARS-CoV-2 illness in children.
- Growing evidence suggests rare, serious complications of SARS-CoV-2 infection in pediatric populations.
Observation:
- Two children presented with limping and joint effusion during the COVID-19 pandemic.
- Both children had preceding fever and mild respiratory tract infections.
- Both children tested positive for SARS-CoV-2.
Findings:
- The children were diagnosed with post-Coronavirus reactive arthritis.
- Successful treatment involved rest and Non-Steroidal Anti-Inflammatory Drugs (NSAID).
- No medical issues were noted during a two-month follow-up.
Implications:
- COVID-19 (Coronavirus Disease 19) may have rheumatogenic potential.
- Physicians, particularly pediatricians, need awareness of this potential complication.
- Timely diagnosis and management of late presentations are crucial.
Background:
Although, preliminary reports of Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection suggest that the infection causes a less severe illness in children, there is now growing evidence of other rare or even serious complications of disease.
Case Presentation:
During the recent COVID-19 pandemic in Kerman, Iran, two children (an 8 year-old boy and a 6 year-old girl) were referred to outpatient Clinic of Pediatric Rheumatology with complaints of limping. Both children had experienced fever and mild respiratory tract infection. At the beginning of the second week of infection, they developed joint effusion. They both tested positive for coronavirus infection and were therefore diagnosed with post Coronavirus reactive arthritis. Both children were treated successfully with rest and Non-Steroidal Anti-Inflammatory Drugs (NSAID). They did not have any medical problems in the two months fallow up.
Conclusions:
These two cases suggest that COVID-19 may be rheumatogenic. Highlighting the need for awareness of physicians, especially pediatricians, regarding the pathogenesis margins of this virus, as late presentations are of great importance.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:30Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:20The JAK-STAT Signaling Pathway