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ChAdOx1 nCoV-19 vaccine: asymptomatic efficacy estimates - Authors' reply
Merryn Voysey1, Andrew J Pollard1
1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, UK.
Lancet (London, England)
|June 13, 2021
Abstract
No abstract available in PubMed .
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For drugs producing a quantal response, onset occurs when plasma concentration reaches a minimum effective level (Cmin). The drug's action duration depends on how long the plasma concentration remains above Cmin.Two primary factors influence this duration: dose size and the rate of drug removal from the action site. Both depend on the drug's redistribution to poorly perfused tissues and elimination processes. A larger dose promotes rapid onset and prolongs the effect's duration.Consider a...
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