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Updated: Nov 2, 2025

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
A Standardized Extubation Schedule Reduces Respiratory Events After Extubation Following Mandibular Distraction in
Yingyi Xu1, Yonghong Tan1, Na Zhang1
1Department of Anaesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Insights
Implementing a standardized extubation protocol for infant mandibular distraction osteogenesis (MDO) significantly reduced post-extubation respiratory events. This protocol improves patient outcomes compared to traditional management.
Area of Science:
- Pediatric surgery
- Anesthesiology
- Critical care medicine
Background:
- Mandibular distraction osteogenesis (MDO) is a surgical procedure for infant craniofacial abnormalities.
- The optimal timing for extubation following MDO in infants remains unclear.
- Respiratory complications are a concern in the postoperative period.
Purpose of the Study:
- To evaluate the impact of a standardized extubation protocol on clinical outcomes in infants undergoing MDO.
- To compare respiratory events and other postoperative parameters before and after protocol implementation.
Main Methods:
- Retrospective cohort study of infants (<1 year) undergoing MDO.
- Comparison of two groups: pre-protocol and post-protocol implementation.
- Analysis of respiratory events, mechanical ventilation duration, length of stay, and extubation success.
Main Results:
- The protocol group (135 infants) had fewer post-extubation respiratory events (9.6%) compared to the pre-protocol group (142 infants, 21.1%).
- The protocol group showed significantly lower adjusted relative risk (0.46) for respiratory events.
- Patients in the protocol group were heavier, and had shorter operation and anesthesia durations.
Conclusions:
- Standardizing extubation practices in infants undergoing MDO effectively reduces postoperative respiratory events.
- Protocol implementation offers a safer approach compared to traditional extubation management.
Purpose:
The rational time for intubation during early mandibular distraction osteogenesis (MDO) in infants is unknown. To investigate the differences in clinical outcomes following MDO before and after a standardized extubation protocol implementation in infants.
Methods:
A retrospective cohort study was performed for infant patients under 1 year old undergoing MDO. The study population was composed of all patients presenting for evaluation and management who underwent MDO between November 2016 and February 2021. We divided them into 2 groups: the pre-protocol group and the protocol group. The inpatient charts of infants were assessed. The primary outcome was respiratory events after extubation. The secondary outcomes were duration of mechanical ventilation (MV), postoperative length of stay (LOS), and success rate of the first extubation. Other variables included age, sex, weight, height, and information related to diagnosis, distraction, anesthesia, and operation. The logistic regression model and linear regression model were used to calculate unadjusted and adjusted relative risk (RR) and mean difference (MD) for associations between 2 groups and the primary and secondary outcomes.
Results:
There were 142 infants in the pre-protocol group and 135 infants in the protocol group. The patients in the protocol group were heavier in weight than those in the pre-protocol group (P<.05). The Cormack-Lehane grade and the duration of operation and anesthesia were higher and longer in the pre-protocol group than in the protocol group (P<.05). Respiratory events after extubation were significantly more common in the pre-protocol group than in the protocol group [21.1 vs. 9.6%, adjusted relative risk 0.46 (95% CI 0.22-0.89), P <.01].
Conclusions:
Among infants undergoing MDO, the standardization of extubation practices can reduce respiratory events after extubation compared with traditional management.
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