Tailoring metal-organic frameworks-based nanozymes for bacterial theranostics

Area of Science:

• Biomaterials Science
• Nanotechnology
• Catalysis

Background:

• Nanozymes offer advantages like stability and high surface area but suffer from limited selectivity and moderate activity.
• Metal-organic frameworks (MOFs) present a promising alternative with tunable porous structures and uniformly dispersed active sites, bridging the gap between natural enzymes and nanozymes.
• MOFs can be engineered for specific applications, including bacterial theranostics, by judicious selection of metal ions and organic linkers.

Purpose of the Study:

• To review the design and fabrication of MOFs for biomedical applications.
• To demonstrate the utility of MOFs in bacterial theranostics, encompassing both diagnostic and therapeutic aspects.
• To identify current challenges and future opportunities in the development of MOF-based nanozymes.

Main Methods:

• Fabrication of MOFs with tailored structures and properties.
• Evaluation of MOF performance in bacterial theranostic applications.
• Assessment of safety considerations associated with MOF usage.

Main Results:

• MOFs exhibit superior catalytic activity and selectivity compared to traditional nanozymes.
• Engineered MOFs demonstrate significant potential for effective bacterial theranostics.
• The review outlines key obstacles and promising avenues for advancing MOF-based nanozyme research.

Conclusions:

• MOFs represent a significant advancement in artificial enzyme technology, particularly for bacterial theranostics.
• MOF-based nanozymes possess unique physicochemical and enzyme-mimicking properties poised for broad interest in research and biomedical applications.
• Further development in MOF design and application is crucial for realizing their full potential in nanomedicine.