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Related Concept Videos

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
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Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

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The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Administering Oxygen by Nasal Cannula01:29

Administering Oxygen by Nasal Cannula

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Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
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Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

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Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
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Administering Oxygen by Mask01:30

Administering Oxygen by Mask

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Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
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Related Experiment Video

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Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats
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Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

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Therapeutic oxygen delivery by perfluorocarbon-based colloids.

Marie Pierre Krafft1, Jean G Riess2

  • 1University of Strasbourg, Institut Charles Sadron (CNRS), 23 rue du Loess, 67034 Strasbourg, France.

Advances in Colloid and Interface Science
|June 13, 2021
PubMed
Summary

Perfluorocarbon (PFC) nanoemulsions show promise for oxygen delivery in various medical applications, despite earlier setbacks. Advanced PFC colloids offer improved efficacy and new theranostic possibilities for diseases and biotechnologies.

Keywords:
Blood substituteFluorocarbon nanoemulsionHypoxiaMicrobubblePhase-shift emulsionStimuli-responsive colloidUltrasound activation

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Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Perfluorocarbon (PFC)-based oxygen (O2) nanoemulsions, initially developed as blood substitutes, faced setbacks after a clinical trial. However, research continues to demonstrate their potential in diverse medical fields.
  • Despite past challenges, significant evidence supports the efficacy of PFC O2-delivery systems in treating conditions like hypoxia, protecting organs, and enhancing cancer therapies.

Purpose of the Study:

  • To review the current state and future potential of perfluorocarbon (PFC)-based colloidal systems for oxygen delivery.
  • To highlight advancements in PFC nanoemulsions, microbubbles, and phase-shift nanoemulsions for various therapeutic and biotechnological applications.

Main Methods:

  • Review of existing literature on PFC-based oxygen delivery systems.
  • Discussion of the mechanisms of oxygen delivery by PFC nanoemulsions.
  • Analysis of advancements in the design and application of PFC colloids, including microbubbles and phase-shift nanoemulsions.

Main Results:

  • Development of advanced, size-adjustable O2-delivering nanoemulsions with improved shelf-stability.
  • Investigation of alternative O2 delivery options like PFC-stabilized microbubbles and phase-shift nanoemulsions with enhanced properties.
  • Exploration of PFC colloid functionalization and targeting for specific indications, improving efficacy and safety.

Conclusions:

  • PFC-based colloidal systems offer versatile applications beyond oxygen delivery, including diagnostic imaging and targeted therapies.
  • Functionalized PFC colloids and microbubbles present significant theranostic opportunities, combining imaging and therapeutic capabilities.
  • Continued research into PFC colloids promises expanded applications in medicine and biotechnology, including drug/gene delivery and regenerative medicine.