Serum carbohydrate antigen 72-4 concentrations decrease with age in females but not in males in Beijing, China.
Tongmei Duan1,2, Xun Chen1, Jing Wu1
1Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Annals of Clinical Biochemistry
|June 14, 2021
Summary
Carbohydrate antigen 72-4 (CA72-4) levels are higher in females than males and decrease with age. Reference intervals for CA72-4 in healthy individuals were established, showing gender differences in younger adults but not in older adults.
Area of Science:
- Clinical Chemistry
- Biomarkers
- Oncology
Background:
- Carbohydrate antigen 72-4 (CA72-4) is a tumor marker utilized in cancer diagnosis and monitoring.
- Limited research exists on demographic variations in CA72-4 levels, particularly concerning age and gender in healthy populations.
Purpose of the Study:
- To investigate and establish reference intervals for serum CA72-4 in a healthy population.
- To analyze the influence of age and gender on CA72-4 concentrations.
Main Methods:
- Serum CA72-4 levels were measured in 10,957 healthy individuals.
- Subjects were stratified by gender and age groups (16-45, 46-60, and >60 years).
- Statistical analysis was conducted using SPSS to determine significant differences.
Main Results:
- CA72-4 concentrations were significantly higher in females compared to males.
- Serum CA72-4 levels demonstrated a gradual decrease with increasing age.
- Gender differences in CA72-4 were significant in the 16-60 age group but not in individuals over 60.
Conclusions:
- Established reference intervals for CA72-4 in the local healthy population.
- CA72-4 levels decrease with age, with higher concentrations in females aged 16-60 compared to males.
- Further research is needed to elucidate the mechanisms behind age-related changes in female CA72-4 levels.
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
56
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
56
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
39
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
39
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
101
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
101