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Updated: Nov 2, 2025
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Biological Treatments of Neurofibromatosis Type 2 and Other Skull Base Disorders
Scott Raskin1, Miriam Bornhorst2
1Gilbert Family Neurofibromatosis Institute, Children's National Hospital, 111 Michigan Avenue Northwest, Washington, DC 20010, USA; Department of Pediatric Hematology-Oncology.
Abstract:
Studies of genomic alterations that occur in skull base tumors have provided information regarding biological aberrations that are necessary for the growth and maintenance of these tumors. This has led to the development and initiation of clinical trials incorporating biological treatments for many skull base tumors. The exciting developments of molecularly targeted therapy for the treatment of skull base tumors may provide noninvasive therapeutic options for patients that can be used either alone or in combination with surgery and/or radiation therapy. Future analysis and continued scientific discovery of treatments for skull base tumors can lead to improved outcomes in patients.
Insights
Genomic studies reveal biological aberrations driving skull base tumors. Molecularly targeted therapies offer new, less invasive treatment options, potentially improving patient outcomes.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Genomic alterations are crucial for skull base tumor growth and maintenance.
- Understanding these aberrations is key to developing targeted treatments.
Purpose of the Study:
- To review the role of genomic alterations in skull base tumors.
- To highlight the potential of molecularly targeted therapies.
Main Methods:
- Review of existing studies on skull base tumor genomics.
- Analysis of clinical trial data for biological treatments.
Main Results:
- Genomic insights have spurred the development of targeted therapies.
- Molecularly targeted therapy shows promise as a noninvasive option.
Conclusions:
- Targeted therapies may be used alone or with surgery/radiation.
- Continued research into skull base tumor treatments is essential for better patient outcomes.
