Related Experiment Video

Updated: Nov 2, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.0K

Low bleeding and thromboembolic risk with continued dabigatran during cardiovascular interventions: the GLORIA-AF

Sake J van der Wall1, Gregory Y H Lip2, Christine Teutsch3

  • 1Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands; Department of Cardiology, OLVG Hospital, Amsterdam, the Netherlands.

European Journal of Internal Medicine
|June 14, 2021
PubMed

Insights

Uninterrupted dabigatran therapy is safe and effective for patients undergoing cardiovascular procedures like AF-cardioversions. This anticoagulant management showed low risks of stroke, systemic embolism, and major bleeding in a real-world setting.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • Limited data exists on managing non-vitamin-K-antagonist oral anticoagulants (NOACs) during cardiovascular interventions.
  • Assessing dabigatran's safety and effectiveness during procedures like atrial fibrillation (AF) cardioversions, ablations, and coronary interventions is crucial.

Purpose of the Study:

  • To evaluate the safety and effectiveness of uninterrupted dabigatran therapy in patients undergoing various cardiovascular interventions.
  • To analyze dabigatran management strategies during AF-cardioversions, AF-ablations, pacemaker implantations, and coronary angiography/stenting.

Main Methods:

  • Prospective data collection from the international GLORIA-AF registry program.
  • Follow-up of newly diagnosed AF patients on dabigatran for up to 2 years.
  • Primary outcome assessment of stroke/systemic embolism and major bleeding within 8 weeks post-intervention.

Main Results:

  • 69% of 599 cardiovascular interventions were performed with uninterrupted dabigatran.
  • Low rates of major bleeding (0.25%) and systemic embolic events (0.25%) observed post-intervention.
  • Most interventions with uninterrupted dabigatran were AF-cardioversions (84%).

Conclusions:

  • Uninterrupted dabigatran therapy is frequently used and associated with low risks of major bleeding and thromboembolic events.
  • These findings support dabigatran's favorable safety and effectiveness profile in real-world clinical practice.
  • Further research may explore optimal dabigatran management across diverse cardiovascular procedures.
Abstract

Keywords:
CardiovascularDabigatranInterventionsNonvitamin-K-antagonistOral anticoagulant

More Related Videos

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.4K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.5K

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.5K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
86
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.1K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
792
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
63
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
85