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Antiarrhythmic action of naloxone: direct, non-opiate effect on the rat heart
1Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel.
Life Sciences
|January 1, 1988
Abstract:
The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.