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Cell/Bacteria-Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy
Hong Pan1, Mingbin Zheng1,2, Aiqing Ma1
1Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055, China.
Advanced Materials (Deerfield Beach, Fla.)
|June 14, 2021
Summary
Cell and bacteria-derived materials offer promising personalized cancer therapy by targeting tumors and modulating the immune system. These bioactive agents overcome treatment barriers, enhancing efficacy for precision medicine approaches.
Area of Science:
- Biomedical Engineering
- Cancer Research
- Immunology
Background:
- Cancer precision medicine faces limitations due to drug resistance, side effects, and low efficacy.
- Tumor complexities like altered targets and immunosuppression hinder treatment outcomes.
- Cell/bacteria-derived materials show potential for personalized cancer therapy.
Purpose of the Study:
- To summarize recent advances in cell/bacteria-based bioactive materials for cancer immune modulation and precision therapy.
- To review strategies for engineering these materials to overcome biological barriers and immunosuppression.
- To discuss ongoing trials and future prospects of personalized bioactive agents, including biorobotics.
Main Methods:
- Review of literature on cell/bacteria-derived bioactive materials for cancer therapy.
- Analysis of strategies for engineering cell/bacteria for enhanced targeting and immune modulation.
- Discussion of clinical trials and emerging agents like cell/bacteria-based micro/nano-biorobotics.
Main Results:
- Cell/bacterial constituents (membranes, vesicles) possess inherent targeting and antitumor properties.
- Engineering strategies can enhance the ability of cell/bacteria to overcome tumor microenvironments.
- Personalized bioactive materials, including biorobotics, show promise for future cancer treatment.
Conclusions:
- Cell/bacteria-derived materials are effective tools for immune modulation and precision cancer therapy.
- Engineering these agents can improve their efficacy against complex tumors.
- Future research into personalized bioactive materials holds significant therapeutic potential.
Keywords:
cell/bacteria bioactive materialsimmunomodulationliving drugmicro/nano-bioroboticsprecise therapytargeting deliveryMore Related Videos
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