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Updated: Nov 2, 2025

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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Role of the CX3CL1-CX3CR1 axis in renal disease

Diana Hamdan1,2, Lisa A Robinson1,2,3

  • 1Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

American Journal of Physiology. Renal Physiology
|June 14, 2021
PubMed

Insights

Fractalkine (CX3CL1) plays a complex role in kidney disease, influencing immune cell infiltration. Understanding its regulation is key to developing new therapies and biomarkers for kidney conditions.

Area of Science:

  • Immunology
  • Nephrology
  • Molecular Biology

Background:

  • Immune cell infiltration is central to kidney diseases.
  • Chemokines, including fractalkine (CX3CL1), drive this infiltration.
  • CX3CL1 has unique transmembrane and soluble forms with distinct functions.

Purpose of the Study:

  • To review the diverse roles of CX3CL1 in kidney disease.
  • To explore CX3CL1 as a potential therapeutic target.
  • To evaluate CX3CL1 as a novel biomarker for kidney conditions.

Main Methods:

  • Literature review of studies on CX3CL1 and kidney disease.
  • Analysis of the CX3CL1-CX3CR1 axis functions.
  • Examination of CX3CL1 regulation in renal pathology.

Main Results:

  • CX3CL1 acts as both a chemoattractant and adhesion molecule.
  • Beyond leukocyte recruitment, CX3CL1 influences cell survival and cytotoxicity.
  • The CX3CL1-CX3CR1 axis exhibits both detrimental and protective effects in kidney diseases.

Conclusions:

  • CX3CL1 has multifaceted roles in kidney disease pathogenesis.
  • Targeting the CX3CL1-CX3CR1 axis offers therapeutic potential.
  • Further understanding of CX3CL1 regulation is crucial for clinical applications.

Keywords:
chemokine (C-X3-C motif) receptor 1chemokinesfractalkineinflammationkidney disease

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