An algorithm combining VVSYmQ® and VCSS scores may help to predict disease severity in C2 patients

Area of Science:

• Vascular Medicine
• Medical Diagnostics
• Patient-Reported Outcomes

Background:

• Chronic venous disease (C2) severity assessment is crucial for treatment decisions.
• Current assessment often relies on physician-reported scores, potentially missing patient perspectives.
• Integrating patient-reported outcomes offers a more comprehensive view of disease burden.

Purpose of the Study:

• To evaluate if combining VVSymQ® (patient-reported) and VCSS (physician-reported) scores effectively stratifies C2 disease severity.
• To determine the correlation and concordance between these two scoring systems in C2 patients.

Main Methods:

• Data from 210 C2 patients in the VANISH-1 and VANISH-2 cohorts were analyzed.
• Pearson's correlation and frequency distribution analyses were used to assess the relationship between VVSymQ® and VCSS.
• Concordance analysis categorized patients based on combined score levels.

Main Results:

• A weak positive correlation (r=0.22, p=0.05) was observed between VVSymQ® and VCSS.
• 61.4% of patients showed low scores in both systems, while 31.3% had elevated scores in both.
• Significant discordance was noted, with only 40.5% having low VVSymQ® and low VCSS, and 2.9% having high VVSymQ® and high VCSS.

Conclusions:

• Combined elevated VVSymQ® and VCSS scores corroborate moderate to severe C2 disease, suggesting potential need for intervention.
• Combined lower scores indicate mild C2 disease, supporting conservative therapy.
• The combination of patient and physician scores provides a more nuanced stratification of C2 disease severity.