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Updated: Nov 2, 2025

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in
Yudai Yonezawa1,2, Fumihiko Ueno1,3, Taku Obara1,3,4
1Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi980-8573, Japan.
Insights
Maternal intake of fruits and vegetables before and during pregnancy may reduce the risk of developmental delays in children. High consumption of vegetables and fruits was linked to better developmental outcomes in offspring aged two years.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Nutritional Science
Background:
- Previous research has established links between maternal diet and offspring's physical growth.
- However, the impact of maternal fruit and vegetable consumption on offspring's neurological development remains under-investigated.
Purpose of the Study:
- To examine the association between maternal fruit and vegetable intake before and during pregnancy and developmental delays in 2-year-old offspring.
Main Methods:
- Utilized data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (23,406 women recruited).
- Assessed fruit and vegetable consumption via Food Frequency Questionnaires (FFQ).
- Evaluated offspring developmental delays using the Ages & Stages Questionnaires, Third Edition (ASQ-3) at 2 years of age.
Main Results:
- Analysis included 10,420 mothers and 10,543 infants; 14.9% of children exhibited developmental delays.
- Higher vegetable consumption (pre-pregnancy to early pregnancy and early to mid-pregnancy) was associated with lower odds of developmental delays (OR 0.74; 95% CI 0.63-0.89 and OR 0.70; 95% CI 0.59-0.84).
- Higher fruit consumption (early to mid-pregnancy) was also linked to reduced odds of developmental delays (OR 0.78; 95% CI 0.66-0.92).
Conclusions:
- High maternal intake of fruits and vegetables before and during pregnancy is associated with a decreased risk of developmental delays in offspring at age two.
- These findings highlight the importance of maternal nutrition for child neurodevelopment.
Abstract:
The association between fruit and vegetable consumption before and during pregnancy and offspring's physical growth has been well reported, but no study has focused on offspring's neurological development. We aimed to explore the association between maternal fruit and vegetable consumption before and during pregnancy and developmental delays in their offspring aged 2 years. Between July 2013 and March 2017, 23 406 women were recruited for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Fruit and vegetable consumption was calculated using FFQ, and offspring's developmental delays were evaluated by the Ages & Stages Questionnaires, Third Edition (ASQ-3) for infants aged 2 years. Finally, 10 420 women and 10 543 infants were included in the analysis. Totally, 14·9 % of children had developmental delay when screened using the ASQ-3. Women in the highest quartile of vegetable consumption from pre-pregnancy to early pregnancy and from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·74; 95 % CI 0·63, 0·89 and OR 0·70; 95 % CI 0·59, 0·84, respectively) than women in the lowest quartile. Women in the highest quartile of fruit consumption from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·78; 95 % CI 0·66, 0·92) than women in the lowest quartile. In conclusion, high fruit and vegetable consumption before and during pregnancy was associated with a lower risk of developmental delays in offspring aged 2 years.
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