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Updated: Nov 2, 2025
Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
Published on: February 13, 2012
Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer
Xiaojing Liang1, Ningxia Zhang1, Hongming Pan1
1Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Abstract:
Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells, and regulates a variety of cellular functions including proliferation, motility, apoptosis, and death. Accumulating evidence has indicated that augmented SOCE is related to the generation and development of cancer, including tumor formation, proliferation, angiogenesis, metastasis, and antitumor immunity. Therefore, the development of compounds targeting SOCE has been proposed as a potential and effective strategy for use in cancer therapy. In this review, we summarize the current research on SOCE inhibitors and blockers, discuss their effects and possible mechanisms of action in cancer therapy, and induce a new perspective on the treatment of cancer.
Insights
Store-operated Ca2+ entry (SOCE) is crucial for cell functions and cancer development. Targeting SOCE with inhibitors offers a promising strategy for effective cancer therapy.
Area of Science:
- Cellular Biology
- Oncology
- Pharmacology
Background:
- Store-operated Ca2+ entry (SOCE) is a primary Ca2+ influx pathway in mammalian cells.
- SOCE regulates critical cellular processes such as proliferation, motility, and apoptosis.
- Aberrant SOCE activity is implicated in cancer initiation, progression, angiogenesis, metastasis, and immune evasion.
Purpose of the Study:
- To review current research on SOCE inhibitors and blockers for cancer therapy.
- To discuss the effects and mechanisms of SOCE-targeting compounds in cancer treatment.
- To offer a new perspective on utilizing SOCE modulation for cancer therapy.
Main Methods:
- Literature review of scientific publications on SOCE and cancer.
- Analysis of existing data on SOCE inhibitors and their efficacy.
- Synthesis of information regarding the mechanisms of action of SOCE blockers in preclinical and clinical studies.
Main Results:
- SOCE plays a significant role in various hallmarks of cancer.
- Numerous compounds targeting SOCE have demonstrated potential anticancer effects.
- Inhibiting SOCE can impede tumor growth, angiogenesis, and metastasis.
Conclusions:
- Targeting SOCE represents a viable therapeutic strategy for cancer treatment.
- Further research into SOCE inhibitors and blockers is warranted to develop novel cancer therapies.
- Modulating SOCE pathways offers a promising avenue for improving antitumor immunity and patient outcomes.
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