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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Exploring the Pathogenesis of Psoriasis Complicated With Atherosclerosis via Microarray Data Analysis.

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This study identifies common molecular mechanisms linking psoriasis and atherosclerosis. Key pathways and hub genes, like chemokines and cytokines, offer new avenues for understanding and treating these interconnected diseases.

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Area of Science:

  • Genomics
  • Immunology
  • Cardiovascular Research

Background:

  • Psoriasis is increasingly linked to atherosclerosis, but the underlying molecular mechanisms remain unclear.
  • Understanding shared pathways is crucial for addressing this comorbidity.

Purpose of the Study:

  • To investigate the shared molecular mechanisms between psoriasis and atherosclerosis.
  • To identify common differentially expressed genes (DEGs) and key pathways involved in both conditions.

Main Methods:

  • Downloaded gene expression profiles for psoriasis (GSE30999) and atherosclerosis (GSE28829) from the Gene Expression Omnibus (GEO) database.
  • Identified common DEGs, performed functional annotation, constructed protein-protein interaction (PPI) networks, and identified hub genes.

Main Results:

  • Identified 94 common DEGs (70 upregulated, 24 downregulated) between psoriasis and atherosclerosis.
  • Functional analysis highlighted the roles of chemokines, cytokines, and the lipopolysaccharide-mediated signaling pathway.
  • Identified 16 key hub genes, including LYN, CSF2RB, IL1RN, and MMP9, involved in the common pathogenesis.

Conclusions:

  • Revealed shared pathogenic pathways and molecular players in psoriasis and atherosclerosis.
  • The identified hub genes and pathways provide novel targets for further research into the common mechanisms.
  • Offers potential insights for developing new therapeutic strategies for patients with both conditions.