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DEPTOR in Skeletal Development and Diseases
Jose Miguel Perez-Tejeiro1,2, Fabiana Csukasi1,2
1Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, IBIMA, University of Málaga, Málaga, Spain.
Abstract:
Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTOR-dependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease.
Insights
DEPTOR regulates the mTOR pathway, impacting skeletal development and homeostasis. This review explores DEPTOR's dual roles in mTOR-dependent and independent pathways, highlighting its relevance in skeletal diseases.
Area of Science:
- Cellular Biology
- Molecular Biology
- Skeletal Biology
Background:
- DEPTOR (DEP-domain containing mTOR-interacting protein) is a regulator of mechanistic target of rapamycin (mTOR).
- DEPTOR was initially identified as a negative regulator of mTOR complexes 1 and 2 (mTORC1, mTORC2).
- Emerging evidence suggests DEPTOR also mediates mTOR-independent cellular responses.
Purpose of the Study:
- To review the current understanding of DEPTOR's function in skeletal biology.
- To explore DEPTOR's involvement in both mTOR-dependent and mTOR-independent pathways.
- To discuss the implications of DEPTOR in skeletal development and disease.
Main Methods:
- Literature review of recent discoveries on DEPTOR and mTOR.
- Analysis of DEPTOR's roles in cellular processes.
- Synthesis of findings related to skeletal development and disease.
Main Results:
- DEPTOR regulates mTOR, a key kinase in cellular processes.
- mTOR is crucial for skeletal development, growth, and homeostasis.
- DEPTOR's dysregulation is linked to various skeletal disorders.
Conclusions:
- DEPTOR plays a significant role in skeletal biology through mTOR-dependent and independent mechanisms.
- Understanding DEPTOR's function is critical for addressing skeletal diseases.
- Further research into DEPTOR pathways may reveal therapeutic targets for skeletal conditions.
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