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Updated: Nov 2, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

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Endothelial dysfunction in patients with lone atrial fibrillation

Kiyan Heshmat-Ghahdarijani1, Shahrzad Jangjoo2, Afshin Amirpour3

  • 1Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

ARYA Atherosclerosis
|June 14, 2021
PubMed

Insights

Lone atrial fibrillation (AF) is linked to systemic endothelial dysfunction, indicated by reduced flow-mediated dilation (FMD). This study highlights AF

Area of Science:

  • Cardiology
  • Vascular Biology
  • Internal Medicine

Background:

  • Atrial fibrillation (AF) is a prevalent tachyarrhythmia in cardiovascular disease (CVD) patients.
  • AF can lead to serious complications, including stroke.
  • Endothelial dysfunction is a key factor in CVD development.

Purpose of the Study:

  • To assess endothelial dysfunction in lone atrial fibrillation (LAF) patients.
  • To utilize flow-mediated dilation (FMD) as a non-invasive marker of endothelial function.
  • To investigate the relationship between LAF and brachial artery endothelial health.

Main Methods:

  • A case-control study design was employed.
  • 43 LAF patients and 51 healthy controls were recruited.
  • Flow-mediated dilation (FMD) of the brachial artery was measured for all participants.

Main Results:

  • No significant differences in gender, heart rate, or systolic blood pressure were observed between groups.
  • Patients with LAF demonstrated significantly lower FMD compared to healthy controls (P = 0.04).

Conclusions:

  • Lone atrial fibrillation is associated with systemic endothelial dysfunction.
  • AF independently contributes to reduced flow-mediated dilation.
  • These findings underscore the vascular impact of AF beyond its arrhythmic nature.
Abstract

Keywords:
ArrhythmiaAtrial FibrillationDysfunction

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