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Updated: Nov 2, 2025
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Endothelial dysfunction in patients with lone atrial fibrillation
Kiyan Heshmat-Ghahdarijani1, Shahrzad Jangjoo2, Afshin Amirpour3
1Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atherosclerosis
|June 14, 2021
Summary
Lone atrial fibrillation (AF) is linked to systemic endothelial dysfunction, indicated by reduced flow-mediated dilation (FMD). This study highlights AF
Area of Science:
- Cardiology
- Vascular Biology
- Internal Medicine
Background:
- Atrial fibrillation (AF) is a prevalent tachyarrhythmia in cardiovascular disease (CVD) patients.
- AF can lead to serious complications, including stroke.
- Endothelial dysfunction is a key factor in CVD development.
Purpose of the Study:
- To assess endothelial dysfunction in lone atrial fibrillation (LAF) patients.
- To utilize flow-mediated dilation (FMD) as a non-invasive marker of endothelial function.
- To investigate the relationship between LAF and brachial artery endothelial health.
Main Methods:
- A case-control study design was employed.
- 43 LAF patients and 51 healthy controls were recruited.
- Flow-mediated dilation (FMD) of the brachial artery was measured for all participants.
Main Results:
- No significant differences in gender, heart rate, or systolic blood pressure were observed between groups.
- Patients with LAF demonstrated significantly lower FMD compared to healthy controls (P = 0.04).
Conclusions:
- Lone atrial fibrillation is associated with systemic endothelial dysfunction.
- AF independently contributes to reduced flow-mediated dilation.
- These findings underscore the vascular impact of AF beyond its arrhythmic nature.
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