Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

610
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
610
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

840
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
840
Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

1.6K
The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
1.6K
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview01:13

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview

715
Attenuated total reflectance (ATR) infrared spectroscopy is a powerful analytical technique used to study the composition of materials. It is widely employed in chemistry, materials science, forensic science, and other fields where sample characterization is required. ATR has several advantages over traditional transmission IR spectroscopy, including the requirement of little to no sample preparation and the ability to analyze a wide range of samples.
The ATR process begins by directing a beam...
715

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Situ Raman Spectroscopy Reveals the Dynamic Evolution and Ethanol Dependence of SEI Structure in Li-Mediated N<sub>2</sub> Reduction Reaction.

Journal of the American Chemical Society·2026
Same author

AirNet: A Deep Learning-Driven Auto Baseline Correction Algorithm Balancing Global Smoothness and Local Fidelity.

Analytical chemistry·2026
Same author

Water-dispersible perovskite nanocrystals: synthesis strategies, ion sensing applications, and future prospects.

RSC advances·2026
Same author

MARCH6 Confers Protection Against Endoplasmic Reticulum Autophagy in Gliomas by Destabilizing FAM134B.

Neurochemical research·2026
Same author

Plasmonic nanocavity-enabled universal detection of layer-breathing vibrations in two-dimensional materials.

Light, science & applications·2026
Same author

Facile Electrochemical Two-Step Etching to Improve the Performance of Au Tips in Tip-Enhanced Raman Spectroscopy.

ACS applied materials & interfaces·2026

Related Experiment Video

Updated: Nov 2, 2025

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging
09:46

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging

Published on: April 28, 2022

4.3K

Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments.

Ana Isabel Pérez-Jiménez1, Danya Lyu1, Zhixuan Lu1

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 P. R. China bren@xmu.edu.cn.

Chemical Science
|June 14, 2021
PubMed
Summary

Surface-enhanced Raman spectroscopy (SERS) offers ultra-sensitive molecular detection. This review explores strategies to overcome challenges, enabling SERS for routine analytical applications.

More Related Videos

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

20.8K
Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy
13:48

Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy

Published on: May 29, 2012

17.3K

Related Experiment Videos

Last Updated: Nov 2, 2025

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging
09:46

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging

Published on: April 28, 2022

4.3K
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

20.8K
Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy
13:48

Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy

Published on: May 29, 2012

17.3K

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biomedicine

Background:

  • Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive vibrational spectroscopy technique.
  • It provides unique molecular fingerprints for analyte identification.
  • Nanotechnology advancements have expanded SERS applications across various scientific fields.

Purpose of the Study:

  • To review current and potential strategies for advancing SERS.
  • To address challenges hindering SERS's transition to routine analytical use.
  • To highlight pathways for practical SERS implementation.

Main Methods:

  • Analysis of existing theoretical and experimental research in SERS.
  • Evaluation of nanotechnology's role in SERS development.
  • Identification of key problems and proposed solutions for SERS translation.

Main Results:

  • SERS demonstrates single-molecule sensitivity and detailed molecular information.
  • Significant research has broadened SERS's scope but practical application remains limited.
  • Various strategies are being developed to enhance SERS performance and reliability.

Conclusions:

  • Addressing current limitations is crucial for SERS to become a routine analytical technique.
  • Continued research and development are essential for realizing SERS's full potential.
  • The review provides insights into strategies for practical SERS translation.