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Updated: Nov 2, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Dandelion flower-like micelles.

Yongchao Yao¹, Deqiu Xu^2,3, Yuhong Zhu¹

¹National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn.

Chemical Science

|June 14, 2021

Summary

This summary is machine-generated.

Researchers created dandelion flower-like micelles (DFMs) that release surface cross-linked micelles (SCMs) under stimuli. These DFMs show enhanced penetration of multicellular tumor spheroids, aiding disease treatment.

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Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery

Background:

Developing advanced drug delivery systems is crucial for treating complex diseases.
Micelles offer potential for targeted delivery, but their penetration capabilities need improvement.
Biomimetic designs can enhance the functionality of nanomaterials.

Purpose of the Study:

To prepare dandelion flower-like micelles (DFMs) using polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs).
To investigate the stimuli-responsive release mechanism of SCMs from DFMs.
To evaluate the enhanced multicellular tumor spheroid (MTS) penetration ability of DFMs.

Main Methods:

Self-assembly of PCL-functionalized SCMs to form DFMs.
Induction of SCM release from DFMs using reductive stimuli.
Measurement of SCM release speed via non-Brownian motion.
Assessment of DFM penetration through MTS models.

Main Results:

DFMs were successfully synthesized via self-assembly.
SCMs were released from DFMs at an average speed of 19.09 μm s^-1 upon reductive stimuli.
DFMs exhibited significantly enhanced penetration through MTS compared to conventional micelles.

Conclusions:

The developed DFMs provide a novel platform for stimuli-responsive drug delivery.
The biomimetic design facilitates superior penetration of biological barriers like MTS.
DFMs hold promise for treating diseases requiring deep tissue penetration, such as cancer and biofilm infections.