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Updated: Nov 2, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Dandelion flower-like micelles
Yongchao Yao1, Deqiu Xu2,3, Yuhong Zhu1
1National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn.
Abstract:
Dandelion flower-like micelles (DFMs) were prepared by self-assembly of polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs). Upon reductive stimuli, the SCMs can be released from the DFMs by non-Brownian motion at an average speed of 19.09 μm s-1. Similar to the property of dandelion flowers dispersing their seeds over a long distance, the DFMs demonstrated enhanced multicellular tumor spheroid (MTS) penetration, a useful property in the treatment of many diseases including cancer, infection-of-biofilm diseases and ocular problems.
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