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"Zombielike" Aggression in Perampanel Overdose.

Rami Z Morsi1, Jeffrey A Katz2

  • 1Neurology, University of Chicago, Chicago, USA.

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Summary
This summary is machine-generated.

Perampanel overdose can cause "zombielike" behavior. This case highlights the need for specific management strategies for perampanel intoxication, improving patient outcomes.

Keywords:
adverse effectantiepileptic drugepilepsyperampanelsuicide attempt

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Perampanel is an antiepileptic medication targeting glutamate receptors.
  • Limited information exists regarding the management of perampanel intoxication.

Observation:

  • An 18-year-old male presented with aggressive,
  • zombielike

Findings:

  • The patient intentionally overdosed on approximately 128 mg of perampanel.
  • Continuous dexmedetomidine infusion and intravenous lorazepam effectively managed the central nervous system effects.
  • Symptoms gradually improved over five days in the intensive care unit.

Implications:

  • This case underscores the potential for severe central nervous system adverse effects from perampanel overdose.
  • Increased awareness is crucial for developing effective, tailored management protocols for perampanel toxicity.