"Zombielike" Aggression in Perampanel Overdose

Area of Science:

• Neurology
• Pharmacology

Background:

• Perampanel is an antiepileptic medication targeting glutamate receptors.
• Limited information exists regarding the management of perampanel intoxication.

Observation:

• An 18-year-old male presented with aggressive,
• zombielike

Findings:

• The patient intentionally overdosed on approximately 128 mg of perampanel.
• Continuous dexmedetomidine infusion and intravenous lorazepam effectively managed the central nervous system effects.
• Symptoms gradually improved over five days in the intensive care unit.

Implications:

• This case underscores the potential for severe central nervous system adverse effects from perampanel overdose.
• Increased awareness is crucial for developing effective, tailored management protocols for perampanel toxicity.