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Chess Not Checkers: Complexities Within the Myeloid Response to the Acute Kidney Injury Syndrome
William T Nash1, Mark D Okusa1
1Division of Nephrology, Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, United States.
Frontiers in Medicine
|June 14, 2021
Summary
Immune cells called macrophages are key in acute kidney injury (AKI). Understanding their role in kidney inflammation or repair is crucial for developing new AKI treatments.
Area of Science:
- Nephrology
- Immunology
- Cell Biology
Background:
- Immune dysregulation is central to acute kidney injury (AKI) pathogenesis.
- Macrophages are dynamic immune cells crucial for tissue homeostasis and inflammation.
- These cells are abundant in the kidney and influence injury and repair processes.
Purpose of the Study:
- To review the current understanding of macrophage and myeloid cell roles in AKI.
- To explore how these cells regulate kidney inflammation and resolution.
- To identify knowledge gaps in AKI pathogenesis and therapeutic strategies.
Main Methods:
- Literature review of studies on macrophages and myeloid cells in AKI.
- Analysis of evidence regarding the regulation and function of these cells in kidney injury.
- Identification of research barriers and future directions.
Main Results:
- Macrophages are pivotal in orchestrating immune responses during AKI.
- These cells can promote either pathogenic inflammation or tissue repair.
- Their dynamic behavior significantly impacts the kidney microenvironment.
Conclusions:
- Understanding macrophage dynamics in AKI is essential for disease insight.
- Targeting myeloid cell functions may offer novel therapeutic interventions for AKI.
- Further research is needed to address knowledge gaps in AKI pathogenesis.
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