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Methods Of Healthcare Delivery System01:26

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Development of Leishmania Species Strains with Constitutive Expression of eGFP
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Green Approach: ''A Forwarding Step for Curing Leishmaniasis-A Neglected Tropical Disease''.

Lakshika Sharma1, Mamta Dhiman1, Abhijeet Singh1

  • 1Department of Biosciences, Manipal University Jaipur, Jaipur, India.

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Summary

This review covers leishmaniasis treatments, including drugs, natural compounds, and metal/metal oxide nanoparticles (NPs). Nanoparticles show promise for treating leishmaniasis and developing new vaccines.

Keywords:
green routeleishmaniasisnanobiotechnanoformulationsnatural sources

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Area of Science:

  • Parasitology
  • Nanotechnology
  • Pharmacology

Background:

  • Leishmaniasis is a serious vector-borne disease with limited treatment options.
  • Current therapies for leishmaniasis face challenges such as drug resistance and toxicity.
  • Natural compounds and nanotechnology offer alternative therapeutic strategies.

Purpose of the Study:

  • To review current therapeutic approaches for leishmaniasis.
  • To explore the potential of natural compounds in leishmaniasis treatment.
  • To evaluate the role of metal and metal oxide nanoparticles (NPs) in leishmaniasis therapy and vaccine development.

Main Methods:

  • Literature review of existing studies on leishmaniasis treatments.
  • Analysis of research on natural compounds and their efficacy.
  • Examination of studies involving various metallic NPs (e.g., silver, gold, zinc oxide) for leishmaniasis treatment.

Main Results:

  • Conventional drugs have limitations in treating leishmaniasis.
  • Natural compounds demonstrate potential therapeutic benefits.
  • Metallic NPs, including silver, gold, and zinc oxide, show curative effects against leishmaniasis.
  • NP formulations are being investigated for vaccine development against leishmaniasis.

Conclusions:

  • Metal/metal oxide nanoparticles represent a promising frontier in leishmaniasis treatment.
  • Further research into NP-based therapies and vaccines is warranted.
  • Nanotechnology offers novel strategies to combat leishmaniasis.