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The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
Randa M Breikaa1,2, Brenda Lilly1,3
1Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States.
Frontiers in Cardiovascular Medicine
|June 14, 2021
Summary
COVID-19 causes cardiovascular issues like heart rhythm problems and blood clots. The Notch pathway plays a key role in these complications by influencing viral entry, inflammation, and coagulation during SARS-CoV-2 infection.
Area of Science:
- Cardiovascular Medicine
- Virology
- Molecular Biology
Background:
- COVID-19 presents with diverse cardiovascular sequelae, including arrhythmias, myocardial injury, myocarditis, and thrombosis.
- The pathogenesis of SARS-CoV-2 involves viral entry, inflammatory responses, and coagulation system activation.
Purpose of the Study:
- To explore the intricate links between SARS-CoV-2 pathophysiology and the Notch signaling pathway.
- To elucidate how Notch pathway dysregulation contributes to COVID-19-associated cardiovascular complications.
Main Methods:
- Literature review synthesizing current research on COVID-19 cardiovascular effects.
- Analysis of the molecular mechanisms connecting SARS-CoV-2 infection and Notch pathway signaling.
- Examination of the role of Notch in inflammation and coagulation relevant to COVID-19.
Main Results:
- The Notch pathway is implicated in viral entry mechanisms of SARS-CoV-2.
- Notch signaling directly influences inflammatory processes central to COVID-19 pathogenesis.
- Dysregulation of the Notch pathway contributes to the pro-thrombotic state observed in COVID-19 patients.
Conclusions:
- The Notch signaling pathway is a critical mediator of cardiovascular complications following COVID-19.
- Targeting the Notch pathway may offer therapeutic strategies for managing COVID-19 cardiovascular sequelae.
- Understanding the interplay between SARS-CoV-2 and Notch signaling is crucial for clinical management.
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