Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Host-Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Photo-Responsive Supramolecular Nanopesticides via Ternary Host-Guest Complexes of Cucurbit[8]uril/Paraquat/Azobenzene on Mesoporous Silica Nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Dual-functional poly(disulfide) enables "Once-and-for-all" atherosclerosis therapy via precision hepatocyte base editing.

Biomaterials·2026
Same author

Tyrosinase Driven-Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management.

Nature communications·2026

Related Experiment Video

Updated: Nov 2, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.6K

Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications.

Zeyu Wang1, Mingju Shui1, Ian W Wyman2

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau 999078 China qwzhang@um.edu.mo rwang@um.edu.mo.

RSC Medicinal Chemistry
|June 14, 2021
PubMed
Summary

Cucurbit[8]uril (CB[8]) forms dynamic supramolecular hydrogels for biomedical uses. These biocompatible hydrogels leverage host-guest interactions for advanced applications.

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.3K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

7.0K

Related Experiment Videos

Last Updated: Nov 2, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.6K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.3K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

7.0K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Cucurbit[n]urils are macrocyclic hosts with large cavities capable of binding multiple guests.
  • Cucurbit[8]uril (CB[8]) uniquely accommodates two guest molecules, enabling its use as a versatile crosslinker.
  • Supramolecular hydrogels offer tunable properties and biocompatibility for diverse applications.

Purpose of the Study:

  • To review the fabrication of supramolecular hydrogels using CB[8] as a dynamic crosslinker over the past decade.
  • To discuss the design principles behind these CB[8]-based hydrogels.
  • To highlight innovative biomedical applications and future prospects of these materials.

Main Methods:

  • Dynamic noncovalent crosslinking of polymers using CB[8].
  • Host-guest complexation driving supramolecular assembly.
  • Fabrication of hydrogel networks via polymer-macrocycle interactions.

Main Results:

  • CB[8] effectively crosslinks polymers to form stable yet dynamic supramolecular hydrogels.
  • These hydrogels exhibit excellent biocompatibility, making them suitable for biomedical applications.
  • A wide range of polymers can be utilized, allowing for tailored material properties.

Conclusions:

  • CB[8]-based supramolecular hydrogels represent a promising class of materials for advanced biomedical applications.
  • The dynamic nature and biocompatibility of these hydrogels are key advantages.
  • Further research into design and application will unlock their full potential in medicine.