Revisiting Solitary Pedunculated Lipofibromas

Area of Science:

• Dermatopathology
• Histology
• Clinical Diagnosis

Background:

• Pedunculated lipofibromas are benign, acquired solitary skin lesions.
• They commonly appear on the buttocks and thighs.
• Distinguishing them from similar conditions like nevus lipomatosus superficialis is clinically important due to varying treatment approaches.

Observation:

• Three cases of solitary pedunculated lipofibromas in older, obese adults were analyzed.
• Histopathology reveals dermal aggregates of mature adipocytes without inflammation.
• Differential diagnoses include fibroepithelial polyps and nevus lipomatosus superficialis.

Findings:

• Pedunculated lipofibromas present as broad-based lesions with dermal fatty infiltration.
• Nevus lipomatosus superficialis typically occurs in younger individuals and presents with multiple cerebriform lesions.
• Clinicopathologic correlation is essential for accurate diagnosis.

Implications:

• The term 'pedunculated lipofibroma' is proposed for solitary, smooth-surfaced fatty lesions in older adults.
• This terminology aids in differentiating these lesions from other lipomatous conditions.
• Accurate diagnosis ensures appropriate management and treatment selection.