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3D-Printed Drug Capture Materials Based on Genomic DNA Coatings
Daryl W Yee1, Steven W Hetts2, Julia R Greer1
1Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California 91125, United States.
ACS Applied Materials & Interfaces
|June 14, 2021
Summary
Researchers developed a 3D-printed device coated with genomic DNA to capture chemotherapy drugs like doxorubicin. This innovation aims to reduce toxic side effects by localizing chemotherapy treatment to the target organ.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Cancer Therapeutics
Background:
- Chemotherapy's toxic side effects limit treatment efficacy.
- Developing targeted cancer therapeutics is a significant challenge.
- Current 3D printing materials lack drug-binding capabilities.
Purpose of the Study:
- To create a 3D-printed device for sequestering chemotherapeutic agents.
- To mitigate off-target toxicity by localizing chemotherapy.
- To develop a stable and effective drug-capture system.
Main Methods:
- Utilized 3D printing for precise device fabrication.
- Coated 3D-printed structures with genomic DNA.
- Employed electrostatic interactions and UV C cross-linking for stable DNA coating.
Main Results:
- Achieved extremely stable DNA coatings with minimal leaching (100 pg/mm² over 30 min).
- Demonstrated *in vitro* doxorubicin capture of 72 ng/mm² in PBS and 60 ng/mm² in human serum.
- Validated the stability and efficacy of the genomic DNA-coated materials.
Conclusions:
- Genomic DNA-coated 3D-printed materials show promise for localized chemotherapy delivery.
- This approach significantly advances the potential for improved chemotherapy treatment with reduced side effects.
- The developed device represents a step towards clinical translation for enhanced cancer therapy.
