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Updated: Nov 2, 2025

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Published on: May 27, 2021

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats.

Esther Vinner¹, Katya Belelovsky¹, Izhar Bar-Gad²

¹The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center, Bar-Ilan University.

Journal of Visualized Experiments : Jove

|June 14, 2021

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Researchers developed new rat models for studying motor tics, crucial for Tourette syndrome. These models use bicuculline to induce tics, allowing detailed investigation of tic generation mechanisms.

Area of Science:

Neuroscience
Animal Models
Movement Disorders

Background:

Motor tics are hallmark symptoms of Tourette syndrome and other tic disorders.
Abnormal basal ganglia inhibition, particularly in the striatum, underlies tic generation.
Previous animal models used local GABAA antagonist application to induce tics.

Purpose of the Study:

To present novel acute and chronic rat models for studying motor tics.
To provide tools for investigating the neural and behavioral mechanisms of tic generation.
To enable diverse experimental approaches including stimulation and recording.

Main Methods:

Developed an acute model using bicuculline microinjections into the dorsal striatum.
Developed a chronic model using continuous bicuculline infusion via mini-osmotic pumps.

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Last Updated: Nov 2, 2025

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Both models allow for implantation of recording and stimulation devices.

Main Results:

The acute model elicits short-lasting motor tics (up to an hour).
The chronic model enables extended tic expression (days to weeks).
Both models facilitate study of cortico-basal ganglia pathway mechanisms.

Conclusions:

Acute and chronic rat models offer complementary approaches to studying motor tics.
The choice of model depends on the specific research question and desired timescale.
These models are valuable for understanding tic pathophysiology and testing interventions.