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Related Experiment Video

Updated: Nov 2, 2025

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

Models for Treating Post-traumatic Headache.

Joshua Kamins^1,2

¹Goldberg Migraine Program, Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA. jkamins@mednet.ucla.edu.

Current Pain and Headache Reports

|June 14, 2021

Summary

This summary is machine-generated.

Understanding the pathophysiology of post-traumatic headache (PTH) is key to effective treatment. New research on inflammatory neuropeptides like calcitonin gene-related peptide (CGRP) offers promising therapeutic avenues for persistent PTH.

Keywords:

Concussion Headache Persistent post-concussion symptoms Post-traumatic headache Traumatic brain injury

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Area of Science:

Neuroscience
Pharmacology
Neurology

Background:

Post-traumatic headache (PTH) is a common consequence of traumatic brain injury (TBI).
The underlying mechanisms of PTH, particularly its persistence, are not fully understood.
Effective treatment strategies are needed, especially for chronic PTH.

Purpose of the Study:

To review the treatment of post-traumatic headache (PTH).
To guide pharmacotherapy selection based on established pathophysiology.
To highlight the role of novel headache medications and multidisciplinary approaches.

Main Methods:

Review of preclinical models of traumatic brain injury (TBI).
Analysis of the role of inflammatory neuropeptides, such as calcitonin gene-related peptide (CGRP).
Discussion of clinical trial data and the interaction with post-concussion symptoms.

Main Results:

Preclinical models reveal inflammatory neuropeptides (e.g., CGRP) are crucial in PTH initiation and persistence.
Identifying patients at risk for persistent PTH is essential for targeted early therapy.
High-powered clinical trials for persistent PTH medications are lacking.
Effective PTH management requires understanding its interplay with persistent post-concussion symptoms.

Conclusions:

Understanding PTH pathophysiology, including the role of CGRP, is vital for effective treatment.
Targeted early interventions for at-risk individuals and robust clinical trials are necessary.
A multidisciplinary approach is often required for managing persistent PTH and associated symptoms.
Novel headache medications and insights from new PTH models promise improved future treatments.