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Updated: Nov 2, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Published on: July 19, 2019

Altered anterior default mode network dynamics in progressive multiple sclerosis.

Giulia Bommarito¹, Anjali Tarun², Younes Farouj²

¹Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland / Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland / Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|June 14, 2021

Summary

This summary is machine-generated.

Progressive multiple sclerosis (PMS) patients show altered brain network dynamics, specifically in the anterior default mode network (aDMN), which correlates with cognitive decline. Understanding these functional network changes is key to managing PMS.

Keywords:

Progressive multiple sclerosis clinical disability default mode network innovation-driven co-activation patterns resting-state functional magnetic resonance imaging

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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Area of Science:

Neuroscience
Clinical Neurology
Brain Imaging

Background:

Brain function modifications are understudied in progressive multiple sclerosis (PMS).
Understanding these changes offers new insights into PMS pathophysiology.

Purpose of the Study:

To characterize resting-state functional network dynamics in PMS patients.
To investigate the relationship between these dynamics and clinical disability.

Main Methods:

Thirty-two PMS patients and 25 healthy controls (HCs) underwent clinical and cognitive assessments.
Dynamic functional network properties were analyzed from transient brain activity.
A 1-year follow-up assessed longitudinal changes in 19 patients and 16 HCs.

Main Results:

PMS patients exhibited reduced dynamic functional activation of the anterior default mode network (aDMN) compared to HCs.
Decreased anti-co-activation between the aDMN and executive control network (ECN) was observed.
Cognitive impairments, including processing speed and visuo-spatial memory, correlated with aDMN dynamic activity.

Conclusions:

PMS is associated with altered aDMN functional recruitment and anti-correlation with the ECN.
The aDMN's dynamic activity and network interactions significantly explain cognitive disability in PMS.