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Aquagenic Keratoderma: Treatment Update.

M Carbonell Pradas1, R Grimalt Santacana1

  • 1Facultat de Medicina i Ciències de la Salut, UIC-Barcelona, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, España.

Actas Dermo-Sifiliograficas
|June 14, 2021
PubMed
Summary
This summary is machine-generated.

Aquagenic keratoderma, a skin condition triggered by water, shows effective treatments. Oral oxybutynin is a promising option for managing this rare dermatosis.

Keywords:
Anti cholinergicsAnti-colinérgicosAquagenic keratodermaBotulinum toxinsHiperhidrosisHyperhidrosisQueratodermia acuagénicaToxina botulínica

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Area of Science:

  • Dermatology
  • Clinical Medicine

Background:

  • Aquagenic keratoderma is a rare acquired skin condition.
  • It presents as water-induced edema and papules.
  • Associated factors include hyperhidrosis, medications, and cystic fibrosis.

Purpose of the Study:

  • To review and evaluate the efficacy of various treatments for aquagenic keratoderma.
  • To identify effective therapeutic options for this dermatosis.

Main Methods:

  • Literature review of case series and reports.
  • Analysis of described treatments for aquagenic keratoderma.

Main Results:

  • Hyperhidrosis-associated aquagenic keratoderma responds well to treatment.
  • Effective treatments for refractory cases include tap water iontophoresis, endoscopic thoracic sympathectomy, botulinum toxin, and oxybutynin.
  • Topical salicylic acid and aluminum salts offer short-term benefits but limited maintenance value.

Conclusions:

  • Oral oxybutynin (5 mg/d) is a highly effective treatment option.
  • Prostaglandin use may be beneficial, warranting further investigation.
  • More research is needed to address remaining questions and hypotheses.