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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Related Experiment Video

Updated: Nov 2, 2025

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
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Optical Coherence Tomography for Neurovascular Disorders.

Vania Anagnostakou1, Giovanni J Ughi1, Ajit S Puri1

  • 1University of Massachusetts Medical School, Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, United States.

Neuroscience
|June 14, 2021
PubMed
Summary

Optical coherence tomography (OCT) offers a promising solution for advanced cerebrovascular disease diagnosis. Despite challenges in intracranial application, recent OCT technological advancements pave the way for its clinical use.

Keywords:
angiographycerebrovascular diseaseintracranial aneurysmintracranial atherosclerosisoptical coherence tomography

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Area of Science:

  • Neuroimaging
  • Vascular Neurology
  • Medical Device Technology

Background:

  • Current cerebrovascular disease diagnosis relies on lumen imaging (CT angiography, MR angiography, DSA), often lacking detail on vessel walls.
  • Magnetic resonance (MR) vessel wall imaging has limitations in resolving small cerebrovascular lesions.
  • Intravascular imaging like ultrasound and optical coherence tomography (OCT) are established in peripheral circulation but face challenges in the intracranial space due to vessel size and complexity.

Purpose of the Study:

  • To review the potential of optical coherence tomography (OCT) for cerebrovascular imaging.
  • To present the rationale for adopting OCT in the diagnosis and characterization of cerebrovascular diseases.
  • To highlight recent technological advancements in OCT enabling intracranial applications.

Main Methods:

  • Review of existing literature on neuroimaging techniques for cerebrovascular disease.
  • Analysis of current limitations in lumen-only and MR vessel wall imaging.
  • Evaluation of technological advancements in OCT probe design and functionality for neurovascular applications.

Main Results:

  • Existing neuroimaging techniques primarily visualize the vessel lumen, with limited resolution for vessel wall pathology.
  • Advances in OCT technology, including probe miniaturization, stiffness, and rotational capabilities, address previous limitations.
  • These OCT advancements suggest feasibility for clinical translation in the intracranial cerebrovasculature.

Conclusions:

  • Optical coherence tomography (OCT) presents a significant advancement over current neuroimaging modalities for cerebrovascular disease.
  • Technological improvements are overcoming barriers to the intracranial application of OCT.
  • OCT holds promise for enhanced characterization of cerebrovascular pathology, potentially improving diagnosis and treatment.