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Ventilatory effects of naloxone via the sympathoadrenal system in the neonate?
M Srinivasan1, Y Yamamoto, H Lagercrantz
1Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.
Neuroscience Letters
|July 19, 1988
Abstract:
Rabbit pups responded to hypoxia (6% O2 in N2) with a biphasic respiratory pattern, an initial increase by 1 min followed by a decrease. Naloxone (0.8 mg/kg) was found to abolish the declining phase of hypoxia, showing a sustained increase of ventilation throughout the hypoxic challenge. Phentolamine (30 micrograms/kg), an alpha-blocker, had no effect on the normal hypoxic response. However, pretreating the pups with phentolamine and then administering naloxone resulted in a biphasic response to hypoxia. We propose that the naloxone effects on ventilation are mediated in conjunction with the adrenergic system.