Related Experiment Video
Updated: Nov 2, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Recent Advances in C-C/Heteroatom Bond Forming and Annulation Reactions of β- Ketodithioesters
Laishram M Devi1, Thokchom P Singh1, Okram M Singh1
1Department of Chemistry, Manipur University, Canchipur-795003, India.
Abstract:
β-Ketodithioesters (KDEs) are versatile building blocks for the rapid construction of various heterocyclic compounds. Quite a good number of successful reactions based on KDEs have been developed in the past decade for the construction of heterocyclic skeletons under mild conditions. This review covers the new CC/ X bond formation and annulation reactions of KDEs with dielectrophilic or dinucleophilic reagents. Multicomponent reactions using KDEs to construct various heterocycles are also the major contents in this review. Objective: The aim of this review is to bring a fresh perspective on the application of KDEs in organic synthesis covering from 2013 to 2020. Conclusion: From this review, it has been cleared that KDEs have been the object of numerous studies on its use in heterocyclic synthesis. The presence of different functional groups on this synthon permits the incorporation of C-C/X sources into the final targets, which is the significant property of KDEs.
Related Concept Videos
Aldol Condensation with β-Diesters: Knoevenagel Condensation
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Conjugate Addition to α,β-Unsaturated Carbonyl Compounds
Esters to β-Ketoesters: Claisen Condensation Mechanism
C–C Bond Formation: Aldol Condensation Overview
Conjugate Addition of Enolates: Michael Addition

