Related Experiment Video
Updated: Nov 2, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.0K
Covid-19 skin manifestations: an update
Xavier Sanchez-Flores1,2, Thy Huynh1,2, Jennifer T Huang1,2
1Boston Children's Hospital, Dermatology Program.
Current Opinion in Pediatrics
|June 15, 2021
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, can cause various skin conditions in children and adults. Common findings include chilblains-like lesions, while some manifestations like erythema multiforme-like lesions are unique to the pediatric population.
Area of Science:
- Dermatology
- Infectious Diseases
- Pediatrics
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a multisystemic disease.
- COVID-19 presents with respiratory symptoms and can manifest with diverse cutaneous findings.
Purpose of the Study:
- To review SARS-CoV-2 associated cutaneous findings.
- To determine the incidence and relevance of these skin manifestations in the pediatric population.
Main Methods:
- Literature review of studies on COVID-19 and associated skin conditions.
- Analysis of reported cutaneous manifestations in adult and pediatric populations.
Main Results:
- Common COVID-19 skin findings include chilblains-like lesions, maculopapular eruption, urticarial lesions, vesicular lesions, and livedoid lesions.
- Pediatric patients may exhibit erythema multiforme (EM)-like lesions and skin findings related to multisystem inflammatory syndrome in children (MIS-C).
- Livedoid lesions are less common in children.
Conclusions:
- COVID-19 presents with a wide spectrum of cutaneous manifestations.
- Certain skin findings, such as EM-like lesions and MIS-C related rashes, are specific to the pediatric population.
- Management ranges from supportive care for mild cases to intensive care for severe disease.
Related Concept Videos
01:14Changes in Skin Color: Clinical Perspectives
2.7K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.7K
01:23Skin Diseases and Disorders
4.5K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
01:30Skin Cancer
5.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.0K
01:23Role of Skin in Vitamin D Synthesis
6.7K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
6.7K
01:25Endocarditis II: Clinical Features of Infective Endocarditis
72
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
72
01:25Introduction to the Integumentary System
11.6K
The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
11.6K