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Complications of chronic pancreatitis in children

Emily Perito1, Tanja Gonska2, Melena D Bellin3

  • 1Department of Pediatrics, University of California, San Francisco, USA.

Current Opinion in Gastroenterology
|June 15, 2021
PubMed

Insights

Pediatric chronic pancreatitis frequently causes severe pain and malnutrition. Research on larger patient groups provides a clearer understanding of these complications in children.

Area of Science:

  • Pediatric Gastroenterology
  • Pancreatology

Background:

  • Chronic pancreatitis in children is rare but leads to significant complications.
  • Understanding of pediatric chronic pancreatitis has advanced from single-center to multicenter studies.

Purpose of the Study:

  • To review and understand the complications of chronic pancreatitis in children.
  • To highlight the need for improved therapeutic strategies based on recent findings.

Main Methods:

  • Analysis of data from large multicenter and single-center observational studies.
  • Assessment of complications in a larger cohort of pediatric patients.

Main Results:

  • Frequent opioid use for pain management in children with chronic pancreatitis.
  • Prevalence of exocrine pancreatic insufficiency (25%) and pancreatogenic diabetes (6%).
  • Common occurrence of mild malnutrition and low bone density.

Conclusions:

  • Multicenter studies offer a more reliable assessment of chronic pancreatitis complications in children.
  • There is a critical need to investigate and develop effective therapies for pediatric chronic pancreatitis complications.
Abstract

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