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Potential natural candidates in the treatment of coronavirus infections

Faisal Alsenani1

  • 1Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

Saudi Journal of Biological Sciences
|June 15, 2021
PubMed

Insights

Novel natural products offer a promising strategy against viral infections like COVID-19, addressing treatment resistance. Further validation of these natural antiviral compounds is crucial for developing effective therapies.

Area of Science:

  • * Virology and Natural Product Chemistry
  • * Drug Discovery and Development
  • * Infectious Diseases and Public Health

Background:

  • * Many viral infections, including coronavirus disease 2019 (COVID-19), lack effective treatments and exhibit resistance to existing antiviral therapies.
  • * The COVID-19 pandemic has caused significant global health, social, and economic disruption, necessitating urgent development of novel therapeutic interventions.
  • * Traditional medicine, utilizing natural products from plants, marine organisms, and microbes, has historically shown efficacy against viral infections.

Purpose of the Study:

  • * To review and evaluate the potential of natural product-based antiviral compounds for treating viral infections, with a focus on COVID-19.
  • * To assess the application of crude extracts and isolated bioactive compounds from diverse natural sources as therapeutic agents.
  • * To highlight the need for rigorous validation of natural products, including clinical trial data, pharmacokinetic profiles, potency, toxicity, and safety.

Main Methods:

  • * Comprehensive literature review of studies on natural products with antiviral activity.
  • * Analysis of data concerning medicinal plants, marine organisms, and microbial-derived compounds.
  • * Evaluation of existing research on *in vitro* and *in vivo* efficacy, safety, and pharmacokinetic properties of natural product candidates.

Main Results:

  • * Natural products, including extracts and pure compounds from various sources, demonstrate potential antiviral properties against a range of viruses.
  • * Specific examples of bioactive compounds and their mechanisms of action against viral targets are identified.
  • * Significant gaps exist in the validation data for many natural products, particularly regarding clinical evidence and safety profiles.

Conclusions:

  • * Natural products represent a valuable resource for the development of novel antiviral therapies, including those for emerging viral threats like COVID-19.
  • * Systematic validation, encompassing preclinical and clinical studies, is essential to translate the therapeutic potential of natural products into safe and effective treatments.
  • * Further research into natural product-based antivirals could provide crucial alternatives or complements to existing therapeutic strategies.
Keywords:
COVID-19CoronavirusesMERS-CoVNatural antiviral productsSARS-CoV

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